Slow-release clodronate in prevention of inflammation and bone loss associated with adjuvant arthritis.

Osterman, T; Virtamo, T; Laurén, L; Kippo, K; Pasanen, I; Hannuniemi, R; Väänänen, K; Sellman, R

Osterman, T; Virtamo, T; Laurén, L; Kippo, K; Pasanen, I; Hannuniemi, R; Väänänen, K; Sellman, R.

Affiliation

Osterman T; Biomedical Research Center, Leiras Oy, Turku, Finland.

J Pharmacol Exp Ther ; 280(2): 1001-7, 1997 Feb.

Article in En | MEDLINE | ID: mdl-9023317

Subject(s)

Arthritis, Experimental/drug therapy; Arthritis, Experimental/physiopathology; Bone Diseases, Metabolic/prevention & control; Clodronic Acid/therapeutic use; Alkaline Phosphatase/blood; Analysis of Variance; Animals; Arthritis, Experimental/pathology; Bone Density/drug effects; Bone and Bones/drug effects; Bone and Bones/pathology; Calcium/blood; Clodronic Acid/pharmacokinetics; Delayed-Action Preparations; Drug Administration Schedule; Inflammation/prevention & control; Injections, Intravenous; Male; Osteocalcin/blood; Rats; Rats, Inbred Lew

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Collection: 01-internacional Database: MEDLINE Main subject: Arthritis, Experimental / Bone Diseases, Metabolic / Clodronic Acid Type of study: Risk_factors_studies Limits: Animals Language: En Journal: J Pharmacol Exp Ther Year: 1997 Document type: Article

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