Insights into thymic purine metabolism and adenosine deaminase deficiency revealed by transgenic mice overexpressing ecto-5'-nucleotidase (CD73).

Resta, R; Hooker, S W; Laurent, A B; Jamshedur Rahman, S M; Franklin, M; Knudsen, T B; Nadon, N L; Thompson, L F

Resta, R; Hooker, S W; Laurent, A B; Jamshedur Rahman, S M; Franklin, M; Knudsen, T B; Nadon, N L; Thompson, L F.

Affiliation

Resta R; Immunobiology and Cancer Program, Oklahoma Medical Research Foundation, Oklahoma City 73104, USA.

J Clin Invest ; 99(4): 676-83, 1997 Feb 15.

Article in En | MEDLINE | ID: mdl-9045870

Subject(s)

5'-Nucleotidase/biosynthesis; Adenosine Deaminase/deficiency; Purines/metabolism; Thymus Gland/enzymology; Thymus Gland/metabolism; Adenosine/metabolism; Animals; Antibodies, Monoclonal/pharmacology; Apoptosis/immunology; Female; Immunity, Innate; Immunoglobulins/blood; Immunophenotyping; Inosine/metabolism; Lymphocyte Activation; Lymphoid Tissue/cytology; Lymphoid Tissue/enzymology; Male; Mice; Mice, Inbred C3H; Mice, Inbred C57BL; Mice, Transgenic; Purinergic P1 Receptor Agonists; Radiation Chimera; Reproduction/immunology; Survival Analysis; T-Lymphocyte Subsets/immunology; T-Lymphocyte Subsets/radiation effects; Thymus Gland/immunology; Transgenes/immunology

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Full text: 1 Collection: 01-internacional Health context: 6_ODS3_enfermedades_notrasmisibles Database: MEDLINE Main subject: Purines / Thymus Gland / 5'-Nucleotidase / Adenosine Deaminase Limits: Animals Language: En Journal: J Clin Invest Year: 1997 Document type: Article

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