Distributional characteristics of the mRNA for retinoid Z receptor beta (RZR beta), a putative nuclear melatonin receptor, in the rat brain and spinal cord.

Park, H T; Kim, Y J; Yoon, S; Kim, J B; Kim, J J

Park, H T; Kim, Y J; Yoon, S; Kim, J B; Kim, J J.

Affiliation

Park HT; Department of Anatomy, College of Medicine, Pusan National University, South Korea.

Brain Res ; 747(2): 332-7, 1997 Feb 07.

Article in En | MEDLINE | ID: mdl-9046011

ABSTRACT

ABSTRACT

We investigated the distribution of retinoid Z receptor beta (RZR beta), a putative nuclear melatonin receptor, mRNA in the rat brain and spinal cord using in situ hybridization. The RZR beta riboprobe uniquely hybridized with the neurons in several sensory pathways including the dorsal horn of the spinal cord, whereas the regions involved in the motor control were generally unlabeled. RZR beta mRNA was also highly expressed in the dorsomedial portion of the suprachiasmatic nucleus, pars tuberalis and some limbic areas. This result suggests that RZR beta plays a specific role as a transcription factor in the sensory, neuroendocrine and limbic systems.

Subject(s)

Brain Chemistry/physiology; RNA, Messenger/analysis; Receptors, Cell Surface/genetics; Receptors, Cytoplasmic and Nuclear/genetics; Spinal Cord/chemistry; Animals; Brain Stem/chemistry; Diencephalon/chemistry; Female; In Situ Hybridization; Limbic System/chemistry; Mesencephalon/chemistry; Rats; Rats, Sprague-Dawley; Receptors, Melatonin; Telencephalon/chemistry

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Collection: 01-internacional Database: MEDLINE Main subject: Spinal Cord / Brain Chemistry / RNA, Messenger / Receptors, Cytoplasmic and Nuclear / Receptors, Cell Surface Limits: Animals Language: En Journal: Brain Res Year: 1997 Document type: Article

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