Pharmacological characterization of MDL 105,519, an NMDA receptor glycine site antagonist.

Baron, B M; Harrison, B L; Kehne, J H; Schmidt, C J; van Giersbergen, P L; White, H S; Siegel, B W; Senyah, Y; McCloskey, T C; Fadayel, G M; Taylor, V L; Murawsky, M K; Nyce, P; Salituro, F G

Baron, B M; Harrison, B L; Kehne, J H; Schmidt, C J; van Giersbergen, P L; White, H S; Siegel, B W; Senyah, Y; McCloskey, T C; Fadayel, G M; Taylor, V L; Murawsky, M K; Nyce, P; Salituro, F G.

Affiliation

Baron BM; Hoechst Marion Roussel, Cincinnati, OH 45215, USA. brucebaron@hmri.com

Eur J Pharmacol ; 323(2-3): 181-92, 1997 Apr 04.

Article in En | MEDLINE | ID: mdl-9128837

Subject(s)

Excitatory Amino Acid Antagonists/pharmacology; Indoles/pharmacology; Receptors, Glycine/antagonists & inhibitors; Receptors, N-Methyl-D-Aspartate/antagonists & inhibitors; Animals; Anti-Anxiety Agents/pharmacology; Anticonvulsants/pharmacology; Calcium Channels/drug effects; Cells, Cultured; Cerebellum/metabolism; Cyclic GMP/metabolism; Excitatory Amino Acid Agonists/pharmacology; Excitatory Amino Acid Antagonists/metabolism; Indoles/metabolism; Ligands; Male; Mice; Mice, Inbred DBA; Motor Activity/drug effects; N-Methylaspartate/pharmacology; Phencyclidine/analogs & derivatives; Phencyclidine/metabolism; Rats; Rats, Inbred F344; Rats, Wistar; Sodium Channels/drug effects

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Collection: 01-internacional Database: MEDLINE Main subject: Receptors, N-Methyl-D-Aspartate / Receptors, Glycine / Excitatory Amino Acid Antagonists / Indoles Limits: Animals Language: En Journal: Eur J Pharmacol Year: 1997 Document type: Article

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