Major role of the CYP2C isozymes in deamination of amphetamine and benzphetamine: evidence for the quinidine-specific inhibition of the reactions catalysed by rabbit enzyme.

Shiiyama, S; Soejima-Ohkuma, T; Honda, S; Kumagai, Y; Cho, A K; Yamada, H; Oguri, K; Yoshimura, H

Shiiyama, S; Soejima-Ohkuma, T; Honda, S; Kumagai, Y; Cho, A K; Yamada, H; Oguri, K; Yoshimura, H.

Affiliation

Shiiyama S; Faculty of Pharmaceutical Sciences, Kyushu University, Fukuoka, Japan.

Xenobiotica ; 27(4): 379-87, 1997 Apr.

Article in En | MEDLINE | ID: mdl-9149377

Subject(s)

Amphetamine/pharmacokinetics; Aryl Hydrocarbon Hydroxylases; Benzphetamine/pharmacokinetics; Central Nervous System Stimulants/pharmacokinetics; Cytochrome P-450 Enzyme Inhibitors; Enzyme Inhibitors/pharmacology; Isoenzymes/antagonists & inhibitors; Quinidine/pharmacology; Steroid 16-alpha-Hydroxylase; Animals; Cytochrome P-450 Enzyme System/metabolism; Dealkylation; Deamination; In Vitro Techniques; Isoenzymes/metabolism; Male; Microsomes, Liver/enzymology; Rabbits; Rats; Rats, Sprague-Dawley; Species Specificity; Stereoisomerism; Steroid Hydroxylases/antagonists & inhibitors; Steroid Hydroxylases/metabolism; Substrate Specificity

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Collection: 01-internacional Database: MEDLINE Main subject: Quinidine / Benzphetamine / Aryl Hydrocarbon Hydroxylases / Steroid 16-alpha-Hydroxylase / Enzyme Inhibitors / Cytochrome P-450 Enzyme Inhibitors / Amphetamine / Central Nervous System Stimulants / Isoenzymes Limits: Animals Language: En Journal: Xenobiotica Year: 1997 Document type: Article

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