Synthesis and pharmacological characterization of aminocyclopentanetricarboxylic acids: new tools to discriminate between metabotropic glutamate receptor subtypes.

Acher, F C; Tellier, F J; Azerad, R; Brabet, I N; Fagni, L; Pin, J P

Acher, F C; Tellier, F J; Azerad, R; Brabet, I N; Fagni, L; Pin, J P.

Affiliation

Acher FC; Laboratoire de Chimie et Biochimie Pharmacologiques et Toxicologiques, URA 400 CNRS, Université René Descartes-Paris V, France.

J Med Chem ; 40(19): 3119-29, 1997 Sep 12.

Article in En | MEDLINE | ID: mdl-9301676

Subject(s)

Cyclopentanes/chemical synthesis; GABA Agonists/chemical synthesis; GABA Antagonists/chemical synthesis; Receptors, Metabotropic Glutamate/antagonists & inhibitors; Tricarboxylic Acids/chemical synthesis; Animals; Binding, Competitive; Cell Line; Cells, Cultured; Cerebellum/drug effects; Cerebellum/physiology; Cyclopentanes/chemistry; Cyclopentanes/pharmacology; GABA Agonists/chemistry; GABA Agonists/pharmacology; GABA Antagonists/chemistry; GABA Antagonists/pharmacology; Humans; Indicators and Reagents; Inositol/metabolism; Inositol Phosphates/metabolism; Kinetics; Mice; Molecular Conformation; Molecular Structure; Neurons/drug effects; Neurons/physiology; Receptors, Metabotropic Glutamate/classification; Receptors, Metabotropic Glutamate/metabolism; Recombinant Proteins/metabolism; Stereoisomerism; Structure-Activity Relationship; Transfection; Tricarboxylic Acids/chemistry; Tricarboxylic Acids/pharmacology

Search on Google

XML

PubMed Links

Collection: 01-internacional Database: MEDLINE Main subject: Tricarboxylic Acids / Receptors, Metabotropic Glutamate / GABA Antagonists / GABA Agonists / Cyclopentanes Type of study: Prognostic_studies Limits: Animals / Humans Language: En Journal: J Med Chem Year: 1997 Document type: Article

Search on Google

XML

PubMed Links