Activation of a caspase 3-related cysteine protease is required for glutamate-mediated apoptosis of cultured cerebellar granule neurons.

Du, Y; Bales, K R; Dodel, R C; Hamilton-Byrd, E; Horn, J W; Czilli, D L; Simmons, L K; Ni, B; Paul, S M

Du, Y; Bales, K R; Dodel, R C; Hamilton-Byrd, E; Horn, J W; Czilli, D L; Simmons, L K; Ni, B; Paul, S M.

Affiliation

Du Y; Neuroscience Discovery Research, Lilly Research Laboratories, Eli Lilly and Company, Indianapolis, IN 46285, USA.

Proc Natl Acad Sci U S A ; 94(21): 11657-62, 1997 Oct 14.

Article in En | MEDLINE | ID: mdl-9326666

Subject(s)

Caspases; Cerebellum/cytology; Cysteine Endopeptidases/metabolism; Glutamic Acid/toxicity; Neurons/drug effects; Animals; Apoptosis/drug effects; Apoptosis/physiology; Caspase 3; Cells, Cultured; Cerebellum/physiology; Cysteine Proteinase Inhibitors/pharmacology; Cytosol/physiology; Enzyme Activation; Enzyme Precursors/metabolism; Kinetics; Neurons/cytology; Neurons/physiology; Neuroprotective Agents/pharmacology; Neurotoxins; Oligopeptides/pharmacology; Patch-Clamp Techniques; Rats; Rats, Sprague-Dawley; Receptors, Glutamate/physiology

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Cysteine Endopeptidases / Cerebellum / Glutamic Acid / Caspases / Neurons Limits: Animals Language: En Journal: Proc Natl Acad Sci U S A Year: 1997 Document type: Article

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