Specific retinal diacylglycerol and protein kinase C beta isoform modulation mimics abnormal retinal hemodynamics in diabetic rats.

Bursell, S E; Takagi, C; Clermont, A C; Takagi, H; Mori, F; Ishii, H; King, G L

Bursell, S E; Takagi, C; Clermont, A C; Takagi, H; Mori, F; Ishii, H; King, G L.

Affiliation

Bursell SE; Joslin Diabetes Center, Department of Medicine, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA.

Invest Ophthalmol Vis Sci ; 38(13): 2711-20, 1997 Dec.

Article in En | MEDLINE | ID: mdl-9418723

Subject(s)

Diabetes Mellitus, Experimental/physiopathology; Diglycerides/metabolism; Isoenzymes/metabolism; Protein Kinase C/metabolism; Retina/metabolism; Retinal Vessels/physiopathology; Animals; Blood Flow Velocity/physiology; Diabetes Mellitus, Experimental/metabolism; Diacylglycerol Kinase/antagonists & inhibitors; Enzyme Inhibitors/pharmacology; Fluorescein Angiography; Hyperglycemia/metabolism; Hyperglycemia/physiopathology; Indoles/pharmacology; Isoenzymes/antagonists & inhibitors; Male; Maleimides/pharmacology; Piperidines/pharmacology; Protein Kinase C/antagonists & inhibitors; Quinazolines/pharmacology; Quinazolinones; Rats; Rats, Sprague-Dawley; Retina/drug effects; Retina/physiopathology

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Collection: 01-internacional Database: MEDLINE Main subject: Retina / Retinal Vessels / Protein Kinase C / Diabetes Mellitus, Experimental / Diglycerides / Isoenzymes Limits: Animals Language: En Journal: Invest Ophthalmol Vis Sci Year: 1997 Document type: Article

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