AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor.

Donzella, G A; Schols, D; Lin, S W; Esté, J A; Nagashima, K A; Maddon, P J; Allaway, G P; Sakmar, T P; Henson, G; De Clercq, E; Moore, J P

Donzella, G A; Schols, D; Lin, S W; Esté, J A; Nagashima, K A; Maddon, P J; Allaway, G P; Sakmar, T P; Henson, G; De Clercq, E; Moore, J P.

Affiliation

Donzella GA; The Aaron Diamond AIDS Research Center, The Rockefeller University, New York, New York 10016, USA.

Nat Med ; 4(1): 72-7, 1998 Jan.

Article in En | MEDLINE | ID: mdl-9427609

Subject(s)

Anti-HIV Agents/pharmacology; CD4-Positive T-Lymphocytes/physiology; CD4-Positive T-Lymphocytes/virology; Chemokines, CXC; HIV-1/physiology; Heterocyclic Compounds/pharmacology; Receptors, CXCR4/physiology; Antibodies, Monoclonal/pharmacology; Benzylamines; CD4 Antigens/immunology; CD4 Antigens/physiology; CD4-Positive T-Lymphocytes/drug effects; Calcium/metabolism; Carbachol/pharmacology; Cell Fusion; Cell Line; Cells, Cultured; Chemokine CCL5/pharmacology; Chemokine CXCL12; Cyclams; Cytokines/metabolism; Cytokines/pharmacology; HIV Envelope Protein gp120/drug effects; HIV Envelope Protein gp120/metabolism; HIV-1/drug effects; Humans; Interleukin-2/pharmacology; Kinetics; Membrane Fusion/drug effects; Receptors, CCR5/physiology; Receptors, CXCR4/drug effects; Receptors, CXCR4/immunology; Signal Transduction/drug effects; Somatostatin/pharmacology

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Collection: 01-internacional Database: MEDLINE Main subject: CD4-Positive T-Lymphocytes / HIV-1 / Anti-HIV Agents / Receptors, CXCR4 / Chemokines, CXC / Heterocyclic Compounds Limits: Humans Language: En Journal: Nat Med Year: 1998 Document type: Article

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