Mutation at either Arg336 or Arg562 in factor VIII is insufficient for complete resistance to activated protein C (APC)-mediated inactivation: implications for the APC resistance test.

Amano, K; Michnick, D A; Moussalli, M; Kaufman, R J

Amano, K; Michnick, D A; Moussalli, M; Kaufman, R J.

Affiliation

Amano K; Howard Hughes Medical Institute, Department of Biological Chemistry, University of Michigan Medical Center, Ann Arbor 48109-0650, USA.

Thromb Haemost ; 79(3): 557-63, 1998 Mar.

Article in En | MEDLINE | ID: mdl-9531040

Subject(s)

Drug Resistance/genetics; Factor VIII/genetics; Fibrinolytic Agents/pharmacology; Hemophilia A/genetics; Point Mutation; Protein C/pharmacology; Animals; Arginine/genetics; Cricetinae; Humans

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Collection: 01-internacional Database: MEDLINE Main subject: Drug Resistance / Factor VIII / Protein C / Point Mutation / Fibrinolytic Agents / Hemophilia A Limits: Animals / Humans Language: En Journal: Thromb Haemost Year: 1998 Document type: Article

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