4-Amino-2-[4-[1-(benzyloxycarbonyl)-2(S)- [[(1,1-dimethylethyl)amino]carbonyl]-piperazinyl]-6, 7-dimethoxyquinazoline (L-765,314): a potent and selective alpha1b adrenergic receptor antagonist.

Patane, M A; Scott, A L; Broten, T P; Chang, R S; Ransom, R W; DiSalvo, J; Forray, C; Bock, M G

Patane, M A; Scott, A L; Broten, T P; Chang, R S; Ransom, R W; DiSalvo, J; Forray, C; Bock, M G.

Affiliation

Patane MA; Department of Medicinal Chemistry, Merck & Co., Inc., West Point, Pennsylvania 19486, USA.

J Med Chem ; 41(8): 1205-8, 1998 Apr 09.

Article in En | MEDLINE | ID: mdl-9548811

Subject(s)

Adrenergic alpha-1 Receptor Antagonists; Adrenergic alpha-Antagonists/pharmacology; Prazosin/analogs & derivatives; Adrenergic alpha-Antagonists/chemical synthesis; Adrenergic alpha-Antagonists/chemistry; Adrenergic alpha-Antagonists/metabolism; Animals; Antihypertensive Agents/chemical synthesis; Antihypertensive Agents/chemistry; Antihypertensive Agents/pharmacology; Blood Pressure/drug effects; Humans; Male; Organ Specificity; Prazosin/chemical synthesis; Prazosin/chemistry; Prazosin/metabolism; Prazosin/pharmacology; Rats; Rats, Inbred SHR; Rats, Sprague-Dawley; Receptors, Adrenergic, alpha-1/metabolism; Spinal Cord/metabolism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Prazosin / Adrenergic alpha-Antagonists / Adrenergic alpha-1 Receptor Antagonists Limits: Animals / Humans / Male Language: En Journal: J Med Chem Year: 1998 Document type: Article

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