Cyclopropane-derived peptidomimetics. Design, synthesis, evaluation, and structure of novel HIV-1 protease inhibitors.

Martin, S F; Dorsey, G O; Gane, T; Hillier, M C; Kessler, H; Baur, M; Mathä, B; Erickson, J W; Bhat, T N; Munshi, S; Gulnik, S V; Topol, I A

Martin, S F; Dorsey, G O; Gane, T; Hillier, M C; Kessler, H; Baur, M; Mathä, B; Erickson, J W; Bhat, T N; Munshi, S; Gulnik, S V; Topol, I A.

Affiliation

Martin SF; Structural Biochemistry Program, Frederick Biomedical Supercomputing Center, NCI-FCRDC, Frederick, Maryland 21702, USA.

J Med Chem ; 41(10): 1581-97, 1998 May 07.

Article in En | MEDLINE | ID: mdl-9572884

Subject(s)

Cyclopropanes; Drug Design; HIV Protease Inhibitors; HIV Protease/metabolism; Molecular Mimicry; Oligopeptides/chemistry; Binding Sites; Crystallography, X-Ray; Cyclopropanes/chemistry; Cyclopropanes/metabolism; Cyclopropanes/pharmacology; HIV Protease Inhibitors/chemistry; HIV Protease Inhibitors/metabolism; HIV Protease Inhibitors/pharmacology; Kinetics; Magnetic Resonance Spectroscopy; Models, Molecular; Molecular Conformation; Protein Structure, Secondary; Solutions

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Collection: 01-internacional Database: MEDLINE Main subject: Oligopeptides / Drug Design / HIV Protease / HIV Protease Inhibitors / Molecular Mimicry / Cyclopropanes Language: En Journal: J Med Chem Year: 1998 Document type: Article

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