Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain.

Schroeter, E H; Kisslinger, J A; Kopan, R

Schroeter, E H; Kisslinger, J A; Kopan, R.

Affiliation

Schroeter EH; Department of Molecular Biology and Pharmacology, Washington University, St Louis, Missouri 63110, USA.

Nature ; 393(6683): 382-6, 1998 May 28.

Article in En | MEDLINE | ID: mdl-9620803

Subject(s)

DNA-Binding Proteins/metabolism; Membrane Proteins/metabolism; Receptors, Cell Surface; Signal Transduction; Transcription Factors; 3T3 Cells; Amino Acid Sequence; Animals; Basic Helix-Loop-Helix Transcription Factors; Brefeldin A; Cell Line; Cell Nucleus/metabolism; Cyclopentanes/pharmacology; Gene Expression Regulation; Genes, Reporter; Golgi Apparatus/metabolism; Homeodomain Proteins/genetics; Ligands; Mice; Molecular Sequence Data; Monensin/pharmacology; Mutagenesis; Peptide Fragments/metabolism; Promoter Regions, Genetic; Protein Processing, Post-Translational/drug effects; Receptor, Notch1; Transcription Factor HES-1; Transfection

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Collection: 01-internacional Database: MEDLINE Main subject: Transcription Factors / Signal Transduction / Receptors, Cell Surface / DNA-Binding Proteins / Membrane Proteins Type of study: Prognostic_studies Limits: Animals Language: En Journal: Nature Year: 1998 Document type: Article

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