Metabolism of 2(R,S)-1,2-bis(nicotinamido)propane, a new agent with anti-vasospasm activity, in rats and rabbits.

Ishigai, M; Ishitani, Y; Orikasa, Y; Kamiyama, H; Kumaki, K

Ishigai, M; Ishitani, Y; Orikasa, Y; Kamiyama, H; Kumaki, K.

Affiliation

Ishigai M; Drug Metabolism and Pharmacokinetics Laboratory, Chugai Pharmaceutical Co. Ltd., Tokyo, Japan.

Arzneimittelforschung ; 48(5): 429-35, 1998 May.

Article in En | MEDLINE | ID: mdl-9638308

Subject(s)

Antioxidants/pharmacokinetics; Niacinamide/analogs & derivatives; Aldehyde Oxidoreductases/metabolism; Animals; Bile/metabolism; Biotransformation; Cytosol/metabolism; Feces/chemistry; In Vitro Techniques; Liver/enzymology; Liver/metabolism; Male; Mass Spectrometry; Niacinamide/pharmacokinetics; Rabbits; Rats; Rats, Sprague-Dawley

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Collection: 01-internacional Database: MEDLINE Main subject: Niacinamide / Antioxidants Limits: Animals Language: En Journal: Arzneimittelforschung Year: 1998 Document type: Article

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