The molecular mechanism of B cell activation by toll-like receptor protein RP-105.
J Exp Med
; 188(1): 93-101, 1998 Jul 06.
Article
in En
| MEDLINE
| ID: mdl-9653087
ABSTRACT
The B cell-specific transmembrane protein RP-105 belongs to the family of Drosophila toll-like proteins which are likely to trigger innate immune responses in mice and man. Here we demonstrate that the Src-family protein tyrosine kinase Lyn, protein kinase C beta I/II (PKCbetaI/II), and Erk2-specific mitogen-activated protein (MAP) kinase kinase (MEK) are essential and probably functionally connected elements of the RP-105-mediated signaling cascade in B cells. We also find that negative regulation of RP-105-mediated activation of MAP kinases by membrane immunoglobulin may account for the phenomenon of antigen receptor-mediated arrest of RP-105-mediated B cell proliferation.
Full text:
1
Collection:
01-internacional
Database:
MEDLINE
Main subject:
Membrane Glycoproteins
/
B-Lymphocytes
/
Receptors, Cell Surface
/
Drosophila Proteins
Limits:
Animals
Language:
En
Journal:
J Exp Med
Year:
1998
Document type:
Article