Design, synthesis, and biological activities of potent and selective somatostatin analogues incorporating novel peptoid residues.

Tran, T A; Mattern, R H; Afargan, M; Amitay, O; Ziv, O; Morgan, B A; Taylor, J E; Hoyer, D; Goodman, M

Tran, T A; Mattern, R H; Afargan, M; Amitay, O; Ziv, O; Morgan, B A; Taylor, J E; Hoyer, D; Goodman, M.

Affiliation

Tran TA; Department of Chemistry and Biochemistry, University of California at San Diego, La Jolla, California 92093-0343, USA.

J Med Chem ; 41(15): 2679-85, 1998 Jul 16.

Article in En | MEDLINE | ID: mdl-9667958

Subject(s)

Drug Design; Somatostatin/analogs & derivatives; Somatostatin/chemical synthesis; Animals; CHO Cells; Cricetinae; Growth Hormone/blood; Humans; Insulin/blood; Male; Peptide Fragments/pharmacology; Peptoids; Rats; Rats, Wistar; Receptors, Somatostatin/metabolism; Somatostatin/metabolism; Somatostatin/pharmacology; Stereoisomerism; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Somatostatin / Drug Design Type of study: Prognostic_studies Limits: Animals / Humans / Male Language: En Journal: J Med Chem Year: 1998 Document type: Article

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