Cord blood transplantation (CBT) in hemoglobinopathies. Eurocord.

Miniero, R; Rocha, V; Saracco, P; Locatelli, F; Brichard, B; Nagler, A; Roberts, I; Yaniv, I; Beksac, M; Bernaudin, F; Gluckman, E

Miniero, R; Rocha, V; Saracco, P; Locatelli, F; Brichard, B; Nagler, A; Roberts, I; Yaniv, I; Beksac, M; Bernaudin, F; Gluckman, E.

Affiliation

Miniero R; Eurocord Transplant Registry, Unité de Recherche, Hôpital Saint-Louis, Paris, France.

Bone Marrow Transplant ; 22 Suppl 1: S78-9, 1998 Jul.

Article in En | MEDLINE | ID: mdl-9715898

ABSTRACT

ABSTRACT

Patients with beta-thalassemia (Hbeta th) and sickle cell anemia (SCA) can be treated with bone marrow transplantation. Stem cells from cord blood have several theoretical advantages, however, the place of cord blood transplant for hemoglobinopathies has not yet been established. We report here the EUROCORD experience of 10 patients (Hbeta th = 7, SCA = 3) transplanted with related cord blood.

Subject(s)

Anemia, Sickle Cell/therapy; Fetal Blood; Hematopoietic Stem Cell Transplantation; beta-Thalassemia/therapy; Antineoplastic Agents, Alkylating/therapeutic use; Child; Child, Preschool; Cyclosporine/therapeutic use; Female; Graft vs Host Disease/prevention & control; Humans; Immunosuppressive Agents/therapeutic use; Infant; Male; Methotrexate/therapeutic use; Prospective Studies; Thiotepa/therapeutic use; Treatment Outcome

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Collection: 01-internacional Database: MEDLINE Main subject: Beta-Thalassemia / Hematopoietic Stem Cell Transplantation / Fetal Blood / Anemia, Sickle Cell Type of study: Observational_studies Limits: Child / Child, preschool / Female / Humans / Infant / Male Language: En Journal: Bone Marrow Transplant Year: 1998 Document type: Article

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