The antiproliferative and cell cycle effects of 5,6,7, 8-tetrahydro-N5,N10-carbonylfolic acid, an inhibitor of methylenetetrahydrofolate dehydrogenase, are potentiated by hypoxanthine.

Tonkinson, J L; Habeck, L L; Toth, J E; Mendelsohn, L G; Bewley, J; Shackelford, K A; Gates, S B; Ray, J; Chen, V J

Tonkinson, J L; Habeck, L L; Toth, J E; Mendelsohn, L G; Bewley, J; Shackelford, K A; Gates, S B; Ray, J; Chen, V J.

Affiliation

Tonkinson JL; Cancer Research Division, Lilly Research Laboratories, Eli Lilly and Company, Lilly Corporate Center, Indianapolis, Indiana, USA.

J Pharmacol Exp Ther ; 287(1): 315-21, 1998 Oct.

Article in En | MEDLINE | ID: mdl-9765352

Subject(s)

Antineoplastic Agents/pharmacology; Enzyme Inhibitors/pharmacology; Folic Acid/analogs & derivatives; Hypoxanthine/pharmacology; Methylenetetrahydrofolate Dehydrogenase (NADP)/antagonists & inhibitors; Apoptosis/drug effects; Cell Cycle/drug effects; Cell Division/drug effects; Deoxyadenine Nucleotides/metabolism; Drug Synergism; Folic Acid/pharmacology; Humans; Thymine Nucleotides/metabolism; Tumor Cells, Cultured

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Collection: 01-internacional Database: MEDLINE Main subject: Hypoxanthine / Enzyme Inhibitors / Folic Acid / Methylenetetrahydrofolate Dehydrogenase (NADP) / Antineoplastic Agents Limits: Humans Language: En Journal: J Pharmacol Exp Ther Year: 1998 Document type: Article

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