Nonsteroidal anti-inflammatory drugs increase tumor necrosis factor production in the periphery but not in the central nervous system in mice and rats.

Sacco, S; Agnello, D; Sottocorno, M; Lozza, G; Monopoli, A; Villa, P; Ghezzi, P

Sacco, S; Agnello, D; Sottocorno, M; Lozza, G; Monopoli, A; Villa, P; Ghezzi, P.

Affiliation

Sacco S; Laboratory of Neuroimmunology, Mario Negri Institute for Pharmacological Research, Milano, Italy.

J Neurochem ; 71(5): 2063-70, 1998 Nov.

Article in En | MEDLINE | ID: mdl-9798931

Subject(s)

Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Brain/metabolism; Liver/metabolism; Spleen/metabolism; Tumor Necrosis Factor-alpha/biosynthesis; Animals; Arthritis, Experimental/metabolism; Brain/drug effects; Brain Ischemia/metabolism; Encephalomyelitis, Autoimmune, Experimental/metabolism; Ibuprofen/pharmacology; Indomethacin/pharmacology; Joints/metabolism; Lipopolysaccharides/pharmacology; Liver/drug effects; Male; Mice; Mice, Inbred Strains; Rats; Rats, Sprague-Dawley; Spleen/drug effects; Tumor Necrosis Factor-alpha/antagonists & inhibitors

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Collection: 01-internacional Database: MEDLINE Main subject: Spleen / Brain / Anti-Inflammatory Agents, Non-Steroidal / Tumor Necrosis Factor-alpha / Liver Type of study: Prognostic_studies Limits: Animals Language: En Journal: J Neurochem Year: 1998 Document type: Article

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