Endogenous nitric oxide inhibits glucose-induced insulin secretion by suppression of phosphofructokinase activity in pancreatic islets.

Tsuura, Y; Ishida, H; Shinomura, T; Nishimura, M; Seino, Y

Tsuura, Y; Ishida, H; Shinomura, T; Nishimura, M; Seino, Y.

Affiliation

Tsuura Y; Department of Metabolism and Clinical Nutrition, Kyoto University Faculty of Medicine, Kyoto, Japan.

Biochem Biophys Res Commun ; 252(1): 34-8, 1998 Nov 09.

Article in En | MEDLINE | ID: mdl-9813142

Subject(s)

Glucose/physiology; Insulin/metabolism; Islets of Langerhans/physiology; Nitric Oxide/physiology; Phosphofructokinase-1/metabolism; Animals; Calcium/pharmacology; Cerebellum/enzymology; Enzyme Inhibitors/pharmacology; Glucose/pharmacology; In Vitro Techniques; Indazoles/pharmacology; Insulin Secretion; Islets of Langerhans/drug effects; Islets of Langerhans/metabolism; Isoenzymes/biosynthesis; Isoenzymes/genetics; Male; Nitric Oxide Synthase/biosynthesis; Nitric Oxide Synthase/genetics; Nitroprusside/pharmacology; Ornithine/analogs & derivatives; Ornithine/pharmacology; Phosphofructokinase-1/antagonists & inhibitors; Rats; Rats, Wistar

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Collection: 01-internacional Database: MEDLINE Main subject: Islets of Langerhans / Phosphofructokinase-1 / Glucose / Insulin / Nitric Oxide Limits: Animals Language: En Journal: Biochem Biophys Res Commun Year: 1998 Document type: Article

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