Conserved structural features between HLA-DO beta and -DR beta.
Mol Immunol
; 35(13): 885-93, 1998 Sep.
Article
in En
| MEDLINE
| ID: mdl-9839557
HLA-DO is a non-classical MHC class II molecule presumed to play a specialized role in the antigen processing pathway. We have modeled the HLA-DO beta-chain and found its overall structure compatible with the one of DR beta. Functional studies further highlighted the similarity between these beta-chains of the class II family of proteins. Indeed, a mixed heterodimer composed of the DR alpha and a chimeric DO beta-chains presented bacterial superantigens to T cells and was shown to interact with CD4. The implications of such structural conservation for the in vivo functions of HLA-DO are discussed.
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Collection:
01-internacional
Database:
MEDLINE
Main subject:
HLA-DR Antigens
/
HLA-D Antigens
/
Histocompatibility Antigens Class II
Limits:
Animals
/
Humans
Language:
En
Journal:
Mol Immunol
Year:
1998
Document type:
Article