Unsymmetric nonpeptidic HIV protease inhibitors containing anthranilamide as a P2' ligand.

Randad, R S; Lubkowska, L; Eissenstat, M A; Gulnik, S V; Yu, B; Bhat, T N; Clanton, D J; House, T; Stinson, S F; Erickson, J W

Randad, R S; Lubkowska, L; Eissenstat, M A; Gulnik, S V; Yu, B; Bhat, T N; Clanton, D J; House, T; Stinson, S F; Erickson, J W.

Affiliation

Randad RS; Structural Biochemistry Program, AIDS Drug Screening and Development Laboratory, SAIC-Frederick, MD, USA.

Bioorg Med Chem Lett ; 8(24): 3537-42, 1998 Dec 15.

Article in En | MEDLINE | ID: mdl-9934467

Subject(s)

Amides/chemistry; Anti-HIV Agents/chemistry; HIV Protease Inhibitors/chemistry; Amides/metabolism; Animals; Anti-HIV Agents/blood; Anti-HIV Agents/pharmacokinetics; Cell Line; HIV Protease Inhibitors/blood; HIV Protease Inhibitors/pharmacokinetics; Half-Life; Humans; Ligands; Rats; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: HIV Protease Inhibitors / Anti-HIV Agents / Amides Limits: Animals / Humans Language: En Journal: Bioorg Med Chem Lett Year: 1998 Document type: Article

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