Synthesis and nematocidal activity of diarylnonanoids related to malabaricones.

Hosoi, S; Kiuchi, F; Nakamura, N; Imasho, M; Ali, M A; Sasaki, Y; Tanaka, E; Tsumamoto, Y; Kondo, K; Tsuda, Y

Hosoi, S; Kiuchi, F; Nakamura, N; Imasho, M; Ali, M A; Sasaki, Y; Tanaka, E; Tsumamoto, Y; Kondo, K; Tsuda, Y.

Affiliation

Hosoi S; Faculty of Pharmaceutical Sciences, Kanazawa University, Japan.

Chem Pharm Bull (Tokyo) ; 47(1): 37-43, 1999 Jan.

Article in En | MEDLINE | ID: mdl-9987824

ABSTRACT

ABSTRACT

Twenty diarylnonanones were synthesized and their nematocidal activity was examined. Among those, the p-hydroxy compound 16 exhibited the strongest activity comparable to the natural diarylnonanoids, malabaricones A and C. Diarylundecanoid 57 also showed appreciable activity.

Subject(s)

Antinematodal Agents/chemical synthesis; Antinematodal Agents/pharmacology; Resorcinols/chemical synthesis; Resorcinols/pharmacology; Alkanes/chemical synthesis; Alkanes/pharmacology; Drug Evaluation, Preclinical/methods; Structure-Activity Relationship

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Collection: 01-internacional Database: MEDLINE Main subject: Resorcinols / Antinematodal Agents Language: En Journal: Chem Pharm Bull (Tokyo) Year: 1999 Document type: Article

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