Localization of Niemann-Pick C1 protein in astrocytes: implications for neuronal degeneration in Niemann- Pick type C disease.

Patel, S C; Suresh, S; Kumar, U; Hu, C Y; Cooney, A; Blanchette-Mackie, E J; Neufeld, E B; Patel, R C; Brady, R O; Patel, Y C; Pentchev, P G; Ong, W Y

Patel, S C; Suresh, S; Kumar, U; Hu, C Y; Cooney, A; Blanchette-Mackie, E J; Neufeld, E B; Patel, R C; Brady, R O; Patel, Y C; Pentchev, P G; Ong, W Y.

Affiliation

Patel SC; Neurobiology Research Laboratory, Veterans Affairs Connecticut Healthcare System, Newington, CT 06111, USA. patel.shutish_c@west-haven.va.gov

Proc Natl Acad Sci U S A ; 96(4): 1657-62, 1999 Feb 16.

Article in En | MEDLINE | ID: mdl-9990080

Subject(s)

Astrocytes/metabolism; Brain/pathology; Carrier Proteins; Membrane Glycoproteins; Niemann-Pick Diseases/pathology; Proteins/analysis; Amino Acid Sequence; Animals; Antibodies; Astrocytes/pathology; Axons/pathology; Axons/ultrastructure; Brain/cytology; Brain/metabolism; CHO Cells; Cells, Cultured; Cricetinae; Dendrites/pathology; Dendrites/ultrastructure; Female; Fibroblasts; Humans; Immunohistochemistry; Infant, Newborn; Intracellular Signaling Peptides and Proteins; Macaca fascicularis; Male; Mice; Microscopy, Immunoelectron; Molecular Sequence Data; Nerve Degeneration/metabolism; Nerve Degeneration/pathology; Neuroglia/metabolism; Neuroglia/pathology; Neurons/cytology; Neurons/pathology; Niemann-Pick C1 Protein; Niemann-Pick Diseases/metabolism; Proteins/genetics; Proteins/immunology; Recombinant Proteins/biosynthesis; Recombinant Proteins/chemistry; Recombinant Proteins/immunology; Transfection

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Full text: 1 Collection: 01-internacional Database: MEDLINE Main subject: Brain / Membrane Glycoproteins / Proteins / Carrier Proteins / Niemann-Pick Diseases / Astrocytes Type of study: Prognostic_studies Language: En Journal: Proc Natl Acad Sci U S A Year: 1999 Document type: Article

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