Incidence of depression in patients with hepatitis C treated with direct-acting antivirals
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
; 42(1): 72-76, Jan.-Feb. 2020. tab, graf
Article
em En
| LILACS
| ID: biblio-1055367
Biblioteca responsável:
BR1.1
ABSTRACT
Objective:
Depression has been associated with hepatitis C, as well as with its treatment with proinflammatory cytokines (i.e., interferon). The new direct-acting antiviral agents (DAAs) have minimal adverse effects and high potency, with a direct inhibitory effect on non-structural viral proteins. We studied the incidence and associated factors of depression in a real-life prospective cohort of chronic hepatitis C patients treated with the new DAAs.Methods:
The sample was recruited from a cohort of 91 patients with hepatitis C, of both sexes, with advanced level of fibrosis and no HIV coinfection, consecutively enrolled during a 6-month period for DAA treatment; those euthymic at baseline (n=54) were selected. All were evaluated through the depression module of the Patient Health Questionnaire (PHQ-9-DSM-IV), at three time points baseline, 4 weeks, and end-of-treatment.Results:
The cumulative incidence (95%CI) of major depression and any depressive disorder during DAA treatment was 13% (6.4-24.4) and 46.3% (33.7-59.4), respectively. No differences were observed between those patients with and without cirrhosis or ribavirin treatment (p > 0.05). Risk factors for incident major depression during DAA treatment included family depression (relative risk 9.1 [1.62-51.1]), substance use disorder (11.0 [1.7-73.5]), and baseline PHQ-9 score (2.1 [1.1-3.1]).Conclusions:
The findings of this study highlight the importance of screening for new depression among patients receiving new DAAs, and identify potential associated risk factors.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Temas:
Aperfeicoar_gestao_SUS
Contexto em Saúde:
2_ODS3
Base de dados:
LILACS
Assunto principal:
Antivirais
/
Hepatite C
/
Transtorno Depressivo
Tipo de estudo:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Prognostic_studies
/
Qualitative_research
/
Risk_factors_studies
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
País/Região como assunto:
Europa
Idioma:
En
Revista:
Braz. J. Psychiatry (São Paulo, 1999, Impr.)
Ano de publicação:
2020
Tipo de documento:
Article