Behavioral aspects of GABAergic-dopaminergic interactions in the central nervous system
Eur. j. pharmacol
; 167(1): 117-125, 1989.
Article
em En
| SES-SP, SESSP-IBPROD, SES-SP, SESSP-IBACERVO
| ID: biblio-1062645
Biblioteca responsável:
BR78.1
Localização: BR78.1
ABSTRACT
GABAergic-dopaminergic relationships in rats were analysed quantitatively by means of behavioral studies. Acute and long-term haloperidol administration induced significant leftward displacement of the control dose-response curves for picrotoxin but not those for strychnine or 3-mercaptopropionic acid (3-MPA). Apomorphine given acutely increased the sensitivity of the animal to strychnine but not to picrotoxin or 3-MPA. In animals that presented convulsion a stereotyped gnawing and/or licking behavior was observed immediately after the ictus activity as a consequence of the combined acute administration of haloperidol and picrotoxin. Long-term haloperidol treatment increased the gnawing and/or licking behavior immediately before and/or after the ictus activity induced by picrotoxin (1 and 72 h after haloperidol withdrawal) or 3-MPA (72 h after withdrawal). A possible effect of the drugs employed on the DA-nigroamygdaloid and/or the GABA-striatonigral fiber systems is discussed.
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Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-IBACERVO
/
SESSP-IBPROD
Assunto principal:
Dopaminérgicos
Limite:
Animals
Idioma:
En
Revista:
Eur. j. pharmacol
Ano de publicação:
1989
Tipo de documento:
Article