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Prognostic role of 18F-FDG PET-CT in the prone position in the evaluation of invasive breast carcinoma
Tajima, Carla Chizuru; Lima, Eduardo Nóbrega Pereira; Mello, Ramon Andrade Bezerra de; Marques, Elvira Ferreira; Bitencourt, Almir Galvão Vieira.
Afiliação
  • Tajima, Carla Chizuru; A Beneficência Portuguesa de São Paulo, Imaging Department ­ São Paulo (SP), Brazil. São Paulo. BR
  • Lima, Eduardo Nóbrega Pereira; AC Camargo Cancer Center, Imaging Department ­ São Paulo (SP), Brazil. São Paulo. BR
  • Mello, Ramon Andrade Bezerra de; Universidade Federal de São Paulo, Oncology Department ­ São Paulo (SP), Brazi. São Paulo. BR
  • Marques, Elvira Ferreira; AC Camargo Cancer Center, Imaging Department ­ São Paulo (SP), Brazil. São Paulo. BR
  • Bitencourt, Almir Galvão Vieira; AC Camargo Cancer Center, Imaging Department ­ São Paulo (SP), Brazil. São Paulo. BR
Mastology (Online) ; 31: 1-6, 2021.
Article em En | LILACS-Express | LILACS | ID: biblio-1363669
Biblioteca responsável: BR2499.9
ABSTRACT

Introduction:

The objective of this study was to correlate the features of invasive breast carcinoma in 18F-FDG positron emission tomography/computed tomography with histopathological results, findings from other imaging methods, and survival.

Methods:

This observational single-center study included patients who underwent staging 18F-FDG positron emission tomography/ computed tomography between September 2012 and April 2019; the results were correlated with the findings of other imaging tests and anatomopathological results. Lesions were evaluated for their maximum standardized uptake value on positron emission tomography/computed tomography performed in the prone position. Tumors were classified into three subtypes (luminal, HER2 and triple-negative) based on immunohistochemical analyses.

Results:

A total of 125 patients with a mean age of 52 years (24­90 years) were analyzed. The primary tumor showed an increased 18F-FDG concentration on positron emission tomography/computed tomography in 122 (97.6%) patients, with a mean maximum standardized uptake value of 7.15 (1.0­32.9 range). The mean maximum standardized uptake value was higher in the triple-negative subtype (11.4; n=24) than in the luminal (6.2; n=89) and HER2 (5.0; n=9) subtypes (p<0.01). Tumors with more aggressive histological and immunohistochemical characteristics showed higher maximum standardized uptake values. Patients with a standardized uptake value greater than 7 in the primary tumor or greater than 6.7 in the axillary lymph nodes had poor overall survival (p=0.03 and p<0.01, respectively).

Conclusions:

Our study suggests that the maximum standardized uptake value obtained on positron emission tomography/computed tomography in the prone position may correlate with the tumor immunophenotype and overall survival regardless of the treatments performed, and can be used as a prognostic biomarker in invasive breast carcinoma patients
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Prognostic_studies Idioma: En Revista: Mastology (Online) Ano de publicação: 2021 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Tipo de estudo: Prognostic_studies Idioma: En Revista: Mastology (Online) Ano de publicação: 2021 Tipo de documento: Article