Investigation of maternal polymorphisms in genes related to glucose homeostasis and the influence on birth weight: a cohort study
J. pediatr. (Rio J.)
; 98(3): 296-302, May-June 2022. tab
Artigo
em Inglês
|
LILACS-Express
| LILACS
| ID: biblio-1386088
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract Objectives:
To contribute to a better understanding of the maternal genetic mechanisms that influence obstetric outcomes and that are involved in maternal and child health, this study aimed to evaluate the association between maternal genetic variants and the offspring birth weight by analyzing single-nucleotide polymorphisms (SNPs) in genes related to glucose homeostasis.Methods:
Three polymorphisms were analyzed (GCK rs1799884, TCF7L2 rs7903146 and LEPR rs1137101) in 250 pregnant women who participated in a Brazilian prospective cohort study. Genotyping was performed by Real-Time Polymerase Chain Reaction (qPCR) using pre-designed TaqMan® SNP genotyping assays. Vitamin D dosage was performed by chemiluminescence. Variance, Pearson's chi-square test and multiple linear regression were used for the statistical analysis.Results:
It was possible to verify a significant association between birth weight and maternal GCK rs1799884 when obstetric outcomes, clinical and anthropometric characteristics were taken into consideration. The children of homozygous women for the minor allele GCK rs1799884 presented lower birth weight (β = -335.25, 95% CI = -669.39; -1.17, p = 0.04). Furthermore, a direct link between a leptin receptor variant and gestational duration was found (p = 0.037).Conclusion:
The variant GCK rs1799884 (mm) was associated with a reduction in newborn weight in the miscegenated Brazilian population.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Tipo de estudo:
Estudo de etiologia
/
Estudo observacional
/
Fatores de risco
Idioma:
Inglês
Revista:
J. pediatr. (Rio J.)
Ano de publicação:
2022
Tipo de documento:
Artigo
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