Association of MTR and MTRR genes and oral health-related quality of life in children with dental caries
Braz. oral res. (Online)
; 37: e076, 2023. tab, graf
Article
em En
|
LILACS-Express
| LILACS, BBO
| ID: biblio-1447727
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract This study aimed to assess whether genetic polymorphisms in MTR and MTRR are potential biomarkers of oral health-related quality of life (OHRQoL) in children with caries. A cross-sectional study was designed wherein pairs of parents/caregivers and children (aged two-five years) were selected. Clinical examination was used to detect dental caries, which were classified as low-severity and high-severity caries. The Early Childhood Oral Health Impact Scale (ECOHIS) questionnaire was used to assess OHRQoL. Genomic DNA extracted from the saliva was used to analyze two missense genetic polymorphisms MTR (rs1805087) and MTRR (rs1801394). Mann-Whitney non-parametric test was used to analyze candidate genes with OHRQoL scale and domain, with a significance level of p≤0.05. MTR (rs1805087) was found associated (p = 0.05) with children's OHRQoL subscale scores in the dominant model (GG + AG). Genetic polymorphisms in MTR may increase the risk of poor OHRQoL in children with caries. Further studies are needed to investigate genetics, molecular factors, and OHRQoL.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
BBO
/
LILACS
Tipo de estudo:
Observational_studies
/
Prognostic_studies
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Risk_factors_studies
Aspecto:
Patient_preference
Idioma:
En
Revista:
Braz. oral res. (Online)
Ano de publicação:
2023
Tipo de documento:
Article
/
Project document