Protective Effect of Wolfberry Extract on Acetic Acid-induced Colitis in Rats
West Indian med. j
; 69(5): 356-361, 2021. tab, graf
Article
em En
|
LILACS-Express
| LILACS
| ID: biblio-1515663
Biblioteca responsável:
BR1.1
ABSTRACT
ABSTRACT Objective:
To investigate the protective effect of wolfberry (WB) against acetic acid-induced colitis in rats.Methods:
The rats were divided into four groups with eight rats in each group the control group, WB group, colitis group and WB + colitis group. Distal colitis was induced in rats by intracolonic instillation of 4% acetic acid. Wolfberry + colitis group received 100 mg/kg of WB extract dissolved in saline through the intraperitoneal route for 7 days. Acute colitis was created on the 8th day, and the rats were sacrificed 48 hours later. Colonic damage was assessed by macroscopic and histological criteria as well as biochemical markers.Results:
Mean total antioxidant capacity (TAC), total oxidant status (TOS), tumour necrosis factor (TNF)-α, interleukin (IL)-1β and IL-6 levels were significantly higher in the colitis group compared with the control and WB groups (p < 0.05). The WB + colitis group had significantly lower TAC, TOS, TNF-α, IL-1β and IL-6 levels compared with the colitis group (p < 0.05). The analyses of the histopathological findings indicated that the colitis group had a significantly higher histopathological damage score than the control group (3.12 ± 0.45, 0 ± 0.00, respectively; p < 0.05). Histopathological damage score was significantly higher in the WB + colitis group than in the control group and statistically significantly lower than the colitis group (1.62 ± 0.44, 0 ± 0.00, respectively; 3.12 ± 0.45, respectively; p < 0.05 for both comparisons).Conclusion:
Wolfberry extract is an agent that is effective for preventing acetic acid-induced colitis in rats.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Idioma:
En
Revista:
West Indian med. j
Ano de publicação:
2021
Tipo de documento:
Article