Cortical microarchitecture and remodeling-associated gene expression related to oral cancer prognosis
Braz. oral res. (Online)
; 37: e109, 2023. tab, graf
Article
em En
|
LILACS-Express
| LILACS, BBO
| ID: biblio-1520520
Biblioteca responsável:
BR1.1
ABSTRACT
Abstract The objective of this study was to assess the remodeling-associated gene expression in the mandible of patients diagnosed with oral squamous cell carcinoma (OSCC), investigating the cortical microarchitecture, and their influence on disease-free survival (DFS) and overall survival (OS) rates. A total of twenty-four patients who underwent mandibulectomy for OSCC treatment had two bone fragments harvested from the mandible for gene expression (RANK, RANKL, OPG, and SOST), and microarchitecture analysis, including bone volume, surface, mineral density, degree of anisotropy, and fractal dimension. The prognosis of the patients was assessed. The results revealed that RANK, RANKL, and SOST were predominantly downregulated, while OPG was completely downregulated. Tumors located adjacent to the posterior region of the mandible (p = 0.02), with a bone mineral density below 1.03 g/cm3 HA (p = 0.001), and a bone volume less than 86.47% (p = 0.03) were associated with poor outcomes. In conclusion, bone-remodeling-associated genes exhibited downregulation in the cortex of the mandible in OSCC patients. Additionally, the tumor's location within the mandible, bone volume, and cortical bone mineral density were identified as factors impacting DFS.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
BBO
/
LILACS
Idioma:
En
Revista:
Braz. oral res. (Online)
Ano de publicação:
2023
Tipo de documento:
Article
/
Project document