Diagnosis and management of heparin-induced thrombocytopenia: third edition
Br. j. haematol
; 204(2): 459-475, 20240201.
Article
em En
| BIGG
| ID: biblio-1537647
Biblioteca responsável:
BR1.1
ABSTRACT
This guideline updates and widens the scope of the previ-ous British Society for Haematology (BSH) Clinical guide-lines for Diagnosis and Management of Heparin-Induced Thrombocytopenia Second Edition1 to include functional assays in the diagnosis of heparin-induced thrombocytope-nia (HIT), when to use direct-acting oral anti-coagulants, and the role of intravenous (IV) immunoglobulins and plasma exchange in the management of HIT and spontane-ous HIT.HIT is an immune-mediated, highly pro-thrombotic dis-order of platelet activation caused by pathogenic antibodies against a platelet factor 4 (PF4)heparin complex. It is the most frequent drug-induced immune thrombocytopenia and may lead to life-threatening thrombosis. There are two distinct forms of HIT type I, also known as heparin-asso-ciated thrombocytopenia, which is a non-immunological response to heparin treatment, mediated by a direct interac-tion between heparin and circulating platelets causing plate-let clumping or sequestration, and type II, which is immune mediated.
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AssuntosPalavras-chave
Texto completo:
1
Coleções:
05-specialized
Base de dados:
BIGG
Assunto principal:
Trombocitopenia
/
Plaquetas
Idioma:
En
Revista:
Br. j. haematol
Ano de publicação:
2024
Tipo de documento:
Article