Early and late-onset preeclampsia: effects of DDAH2 polymorphisms on ADMA levels and association with DDAH2 haplotypes
Rev. bras. ginecol. obstet
; Rev. bras. ginecol. obstet;46: 1-6, 2024. tab, graf
Article
em En
| LILACS
| ID: biblio-1559581
Biblioteca responsável:
BR26.1
ABSTRACT
Abstract Objective:
To examine whether the DDAH2 promoter polymorphisms -1415G/A (rs2272592), -1151A/C (rs805304) and -449G/C (rs805305), and their haplotypes, are associated with PE compared with normotensive pregnant women, and whether they affect ADMA levels in these groups.Methods:
A total of 208 pregnant women were included in the study and classified as early-onset (N=57) or late-onset PE (N =49), and as normotensive pregnant women (N = 102).Results:
Pregnant with early-onset PE carrying the GC and GG genotypes for the DDAH2 -449G/C polymorphism had increased ADMA levels (P=0.01). No association of DDAH2 polymorphisms with PE in single-locus analysis was found. However, the G-C-G haplotype was associated with the risk for late-onset PE.Conclusion:
It is suggested that DDAH2 polymorphisms could affect ADMA levels in PE, and that DDAH2 haplotypes may affect the risk for PE.Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Polimorfismo Genético
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Pré-Eclâmpsia
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Haplótipos
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Óxido Nítrico Sintase Tipo III
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Genótipo
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Óxido Nítrico
Limite:
Female
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Humans
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Pregnancy
Idioma:
En
Revista:
RBGO. Revista brasileira de ginecologia e obstetricia
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Rev Bras Ginecol Obstet
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Rev. bras. ginecol. obstet
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Rev. bras. ginecol. obstet. (Online)
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Revista brasileira de ginecologia e obstetrícia (Impresso)
Ano de publicação:
2024
Tipo de documento:
Article