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Schistosomiasis and hepatopulmonary syndrome: the role of concomitant liver cirrhosis
Gonçalves-Macedo, Liana; Lopes, Edmundo Pessoa; Domingues, Ana Lucia Coutinho; Markman Filho, Brivaldo; Mota, Vitor Gomes; Luna, Carlos Feitosa.
Afiliação
  • Gonçalves-Macedo, Liana; Universidade Federal de Pernambuco. Recife. BR
  • Lopes, Edmundo Pessoa; Universidade Federal de Pernambuco. Recife. BR
  • Domingues, Ana Lucia Coutinho; Universidade Federal de Pernambuco. Recife. BR
  • Markman Filho, Brivaldo; Universidade Federal de Pernambuco. Recife. BR
  • Mota, Vitor Gomes; Universidade Federal de Pernambuco. Recife. BR
  • Luna, Carlos Feitosa; Universidade Federal de Pernambuco. Recife. BR
Mem. Inst. Oswaldo Cruz ; 112(7): 469-473, July 2017. tab
Artigo em Inglês | LILACS | ID: biblio-841816
Biblioteca responsável: BR1.1
ABSTRACT
BACKGROUND Hepatopulmonary syndrome (HPS) is defined as an oxygenation defect induced by intrapulmonary vasodilation in patients with liver disease or portal hypertension. It is investigated in patients with liver cirrhosis and less frequently in those with portal hypertension without liver cirrhosis, as may occur in hepatosplenic schistosomiasis (HSS). OBJECTIVES To investigate the prevalence of HPS in patients with HSS, and to determine whether the occurrence of HPS is influenced by concomitant cirrhosis. METHODS We evaluated patients with HSS with or without concomitant liver cirrhosis. All patients underwent laboratory testing, ultrasound, endoscopy, contrast echocardiography, and arterial blood gas analysis. FINDINGS Of the 121 patients with HSS, 64 were also diagnosed with liver cirrhosis. HPS was diagnosed in 42 patients (35%) and was more frequent among patients with concomitant liver cirrhosis than in those without cirrhosis (42% vs. 26%), but the difference was not significant (p = 0.069). HPS was more common in those with spider naevi, Child-Pugh classes B or C and high model for end stage liver disease (MELD) scores (p < 0.05 each). MAIN CONCLUSIONS The prevalence of HPS was 35% in this study. The occurrence of liver cirrhosis concomitantly with HSS may have influenced the frequency of patients presenting with HPS.
Assuntos


Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Saúde e Bem-Estar / Doenças Neglicenciadas Base de dados: LILACS Assunto principal: Esquistossomose mansoni / Síndrome Hepatopulmonar / Cirrose Hepática Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Ano de publicação: 2017 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Contexto em Saúde: ODS3 - Saúde e Bem-Estar / Doenças Neglicenciadas Base de dados: LILACS Assunto principal: Esquistossomose mansoni / Síndrome Hepatopulmonar / Cirrose Hepática Tipo de estudo: Estudo observacional / Estudo prognóstico / Fatores de risco Limite: Feminino / Humanos / Masculino Idioma: Inglês Revista: Mem. Inst. Oswaldo Cruz Ano de publicação: 2017 Tipo de documento: Artigo