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Effects of energetic restriction diet on butyrylcholinesterase in obese women from southern Brazil - A longitudinal study
Santos, Willian dos; Tureck, Luciane Viater; Saliba, Louise Farah; Schenknecht, Caroline Schovanz; Scaraboto, Débora; Souza, Ricardo Lehtonen R; Furtado-Alle, Lupe.
Afiliação
  • Santos, Willian dos; Universidade Federal do Paraná. Departamento de Genética. Laboratório de Polimorfismos e Ligação. Curitiba. BR
  • Tureck, Luciane Viater; Universidade Federal do Paraná. Departamento de Genética. Laboratório de Polimorfismos e Ligação. Curitiba. BR
  • Saliba, Louise Farah; Universidade Federal do Paraná. Departamento de Genética. Laboratório de Polimorfismos e Ligação. Curitiba. BR
  • Schenknecht, Caroline Schovanz; Universidade Federal do Paraná. Departamento de Genética. Laboratório de Polimorfismos e Ligação. Curitiba. BR
  • Scaraboto, Débora; Universidade Federal do Paraná. Departamento de Genética. Laboratório de Polimorfismos e Ligação. Curitiba. BR
  • Souza, Ricardo Lehtonen R; Universidade Federal do Paraná. Departamento de Genética. Laboratório de Polimorfismos e Ligação. Curitiba. BR
  • Furtado-Alle, Lupe; Universidade Federal do Paraná. Departamento de Genética. Laboratório de Polimorfismos e Ligação. Curitiba. BR
Arch. endocrinol. metab. (Online) ; 61(5): 484-489, Sept.-Oct. 2017. tab
Article em En | LILACS | ID: biblio-887597
Biblioteca responsável: BR1.1
ABSTRACT
Objective Butyrylcholinesterase (BChE) activity has been associated with obesity, lipid concentrations, and CHE2 locus phenotypes. This, the aim of this study was to evaluate the effects of an energetic restriction diet intervention on anthropometrical and biochemical variables and on absolute and relative BChE activity in CHE2 C5+ and CHE2 C5- individuals. Subjects and methods One hundred eleven premenopausal obese women from Southern Brazil participated in an energetic restriction diet intervention (deficit of 2500 kJ/day) for 8 weeks. Their anthropometric and biochemical parameters were evaluated before and after the intervention. Plasma BChE activity was measured, and BChE bands in plasma and CHE2 locus phenotypes were detected by electrophoresis. Results The dietetic intervention decreased anthropometric and biochemical parameters as well as absolute BChE activity and relative activity of the G4 band. The CHE2 C5+ phenotype presented a different effect when compared with the CHE2 C5- phenotype. The CHE2 C5+ phenotype showed an effect in absolute BChE activity and in the relative activity of the G4 form, maintaining higher BChE activity regardless of the metabolic changes. Conclusion In our study, 8 weeks was not sufficient time to lower the body mass index to normal, but it was enough to significantly reduce the absolute BChE activity, which became similar to the levels in nonobese individuals. CHE2 C5+ individuals were resistant to the decrease in BChE activity compared to CHE2 C5- individuals. This shows that the diet did not affect the CHE2 and G4 fraction complex and that the products of the CHE2 locus in association with BChE have a role in energy metabolism, maintaining high levels of enzymatic activity even after dietary intervention.
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Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Butirilcolinesterase / Restrição Calórica / Obesidade Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Arch. endocrinol. metab. (Online) Ano de publicação: 2017 Tipo de documento: Article

Texto completo: 1 Coleções: 01-internacional Base de dados: LILACS Assunto principal: Butirilcolinesterase / Restrição Calórica / Obesidade Tipo de estudo: Diagnostic_studies / Observational_studies / Risk_factors_studies Limite: Adult / Female / Humans País/Região como assunto: America do sul / Brasil Idioma: En Revista: Arch. endocrinol. metab. (Online) Ano de publicação: 2017 Tipo de documento: Article