Splenic marginal zone lymphoma: a literature review of diagnostic and therapeutic challenges
Rev. bras. hematol. hemoter
; 39(2): 146-154, Apr.-June 2017. tab, ilus
Article
em En
| LILACS
| ID: biblio-898917
Biblioteca responsável:
BR408.1
Localização: BR408.1
ABSTRACT
ABSTRACT Splenic marginal zone lymphoma (SMZL) is a low-grade B-cell non-Hodgkin's lymphoma characterized by massive splenomegaly, moderate lymphocytosis with or without villous lymphocytes, rare involvement of peripheral lymph nodes and indolent clinical course. As a rare disease, with no randomized prospective trials, there is no standard of care for SMZL so far. Splenectomy has been done for many years as an attempt to control disease, but nowadays it has not been encouraged as first line because of new advances in therapy as rituximab, that are as effective with minimal toxicity. Facing these controversies, this review highlights advances in the literature regarding diagnosis, prognostic factors, treatment indications and therapeutic options.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Prognóstico
/
Neoplasias Esplênicas
/
Esplenomegalia
/
Linfoma não Hodgkin
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Linfoma de Zona Marginal Tipo Células B
Tipo de estudo:
Clinical_trials
/
Diagnostic_studies
/
Prognostic_studies
Idioma:
En
Revista:
Rev. bras. hematol. hemoter
Ano de publicação:
2017
Tipo de documento:
Article