Bj-PRO-5a and Bj-PRO 10c found at C-type natriuretic peptide precursor of bothrops jararaca change renal function of hypertensive rats renal function of hypertensive rats
Int. J. Pept. Res. Ther.
; 23: 381-385, 2017.
Article
em En
| SES-SP, SESSP-IBPROD, SES-SP
| ID: but-ib15039
Biblioteca responsável:
BR78.1
Localização: BR78.1
ABSTRACT
Proline-rich oligopeptides from Bothrops jararaca (Bj-PROs) produce potent and long-lasting antihypertensive effect through mechanisms that go beyond ACE inhibition. In this study we evaluated the renal function parameters of spontaneously hypertensive rats (SHR) injected with Bj-PRO-5a and -10c (0.47, 71 or 710 nmol/kg) found in the CNP-precursor of the snake. At 71 and 710 nmol/kg, Bj-PROs increased urinary flow rate (18.1-43.5%). At 71 nmol/kg, Bj-PRO 5a and 10c elevated sodium excretion (68.1 and 40.9%, respectively) and Bj-PRO-5a also increased urinary sodium/creatinine ratio (56.5%). At 0.47 nmol/kg, Bj-PROs did not change renal function. All doses of Bj-PROs reduced blood pressure (Delta = -13 to -24mmHg). We conclude that Bj-PROs reduce blood pressure and improve renal function of SHRs through diuretic and natriuretic mechanisms.
Texto completo:
1
Coleções:
06-national
/
BR
Base de dados:
SES-SP
/
SESSP-IBPROD
Idioma:
En
Revista:
Int. J. Pept. Res. Ther.
Ano de publicação:
2017
Tipo de documento:
Article