Your browser doesn't support javascript.
loading
Biochemical adjustments to hypoxia by Amazon cichlids
Braz. j. med. biol. res ; 28(11/12): 1257-63, Nov.-Dec. 1995. tab, graf
Artigo em Inglês | LILACS | ID: lil-161528
Biblioteca responsável: BR1.1
RESUMO
The isozyme distribution of cichlid lactate dehydrogenase (LDH) is related to species environmental preferences. Cichlasoma amazonarum. occurs in different environments and presents LDH tissue distribution patterns that correlate with oxygen tension at the capture location. Cichlasoma amazonarum was exposed to long term severe hypoxia (51 days at 36.4 +/- 5.9 mmHg), tissue LDH isozyme distribution was analyzed by electrophoresis and enzyme activities were measured by monitoring the oxidation of NADH as pyruvate was reduced to lactate. The exposure of Cichlasoma amazonarum to long-term severe hypoxia resulted in changes in the tissue distribution of LDH isozymes. The major changes in response to hypoxia occurred in heart, liver and brain isozyme A4 was activated in heart and brain, whereas isozyme B4 was activated in liver. The most significant quantitative change occurred in brain LDH of hypoxia-exposed animals which adopted muscle type kinetics, reflecting a new LDH isozyme distribution. LDH activity was significantly reduced (P<0.05) in animals exposed to hypoxia (N = 8), suggesting an overall LDH suppression. Pyruvate inhibition decreased in all hypoxia-exposed tissues. Thus, the ability of Cichlasoma amazonarum to regulate LDH tissue expression according to oxygen availability allows the animal to survive chronic hypoxic environments. This phenotypic plasticity may occur in other hypoxia-tolerant fish species.
Assuntos
Buscar no Google
Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Percas / L-Lactato Desidrogenase / Hipóxia Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Ano de publicação: 1995 Tipo de documento: Artigo / Congresso e conferência / Documento de projeto

Similares

MEDLINE

...
LILACS

LIS

Buscar no Google
Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Percas / L-Lactato Desidrogenase / Hipóxia Limite: Animais Idioma: Inglês Revista: Braz. j. med. biol. res Ano de publicação: 1995 Tipo de documento: Artigo / Congresso e conferência / Documento de projeto