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Effects of schistosomal mansoni infection on Calomys callosus coelom-associated lymphomyeloid tissue (milky spots)
Mem. Inst. Oswaldo Cruz ; 93(supl.1): 13-23, Oct. 1998. ilus
Article em En | LILACS | ID: lil-218638
Biblioteca responsável: BR15.1
ABSTRACT
Calomys callosus Rengger, 1830 (Rodentia Cricetidae) is a mouse-like South American wild rodent, which is permissive to Schistosoma mansoni infection. In this paper we studied the effect of schistosomal infection in C. callosus mesenteric and omental milky spots (MS), subsidiary foci of coelom-associated lymphomyeloid tissue (CALT), during the acute, transitional (acute to chronic), and chronic phases of the infection. MS were morphologically analyzed by historical methods, using brightfield and confocal laser scanning microscopies. The MS of infected animals were mainly of lymphomyelocytic (42 to 90 days) and lymphoplasmacytic (160 days of infection) types and showed frequent presence of lymphoid follicles with germinal centers, plasmacytogenesis and plasmacytosis, mastocytosis, megakaryopoiesis, erythropoiesis and less pronounced eosinopoiesis. These results indicate that MS are a preferencial site of germinal-center-dependent and independent plasmacytogenesis, and a bone narrow-like organ, committed with various cellular lineages. The consequence of a C. callosus MS reactivity for schistosomal infection is still unknown and is under investigation.
Assuntos
Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: LILACS Assunto principal: Omento / Roedores / Sinais e Sintomas / Esquistossomose mansoni / Arvicolinae / Tecido Linfoide Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Mem. Inst. Oswaldo Cruz Ano de publicação: 1998 Tipo de documento: Article / Congress and conference
Texto completo: 1 Coleções: 01-internacional Contexto em Saúde: 3_ND Base de dados: LILACS Assunto principal: Omento / Roedores / Sinais e Sintomas / Esquistossomose mansoni / Arvicolinae / Tecido Linfoide Tipo de estudo: Risk_factors_studies Limite: Animals Idioma: En Revista: Mem. Inst. Oswaldo Cruz Ano de publicação: 1998 Tipo de documento: Article / Congress and conference