Mannitol in reperfusion skin island flaps injury
Acta cir. bras
; 14(3): 96-9, jul.-set. 1999.
Article
em En
| LILACS
| ID: lil-254235
Biblioteca responsável:
BR1.1
RESUMO
In the skin, the concept of reperfusion injury is well established. The application of this knowledge to deal with skin flap surgery problems, has a great prophylactic potential. This experimental study was performed to evaluate the action of mannitol as a scavenger of oxygen-free radicals, after an ischemia-reperfusion injury on skin island flaps. Thirty six male Wistar rats were divided into three test groups (n = 12) a non-ischemic group (group I), and two others (groups II and III) which were subjected to nine hours of ischemia following by 30 minutes of reperfusion. After seven days, all animals of group II, treated with saline, showed full skin flap necrosis. The assessment of group III, that received a 20 percent solution of mannitol prior to the onset of reperfusion, revealed 75 percent (9/12) of flap viability. These results suggest that pre-treatment with mannitol is able to enhance flaps survival with significantly less tissue necrosis (p<0.02)
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Retalhos Cirúrgicos
/
Reperfusão
/
Manitol
Limite:
Animals
Idioma:
En
Revista:
Acta cir. bras
Ano de publicação:
1999
Tipo de documento:
Article