The prima donna of epigenetics: the regulation of gene expression by DNA methylation
Braz. j. med. biol. res
; 38(10): 1531-1541, Oct. 2005.
Artigo
em Inglês
| LILACS
| ID: lil-409269
Biblioteca responsável:
BR1.1
RESUMO
This review focuses on the mechanisms of DNA methylation, DNA methylation pattern formation and their involvement in gene regulation. Association of DNA methylation with imprinting, embryonic development and human diseases is discussed. Furthermore, besides considering changes in DNA methylation as mechanisms of disease, the role of epigenetics in general and DNA methylation in particular in transgenerational carcinogenesis, in memory formation and behavior establishment are brought about as mechanisms based on the cellular memory of gene expression patterns.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Base de dados:
LILACS
Assunto principal:
Metilação de DNA
/
Inativação Gênica
/
Padrões de Herança
/
Epigênese Genética
/
Neoplasias
Limite:
Animais
/
Humanos
Idioma:
Inglês
Revista:
Braz. j. med. biol. res
Ano de publicação:
2005
Tipo de documento:
Artigo
/
Congresso e conferência
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