A novel human G protein-coupled receptor is over-expressed in prostate cancer
Genet. mol. res. (Online)
; 3(4): 521-531, 2004. ilus, tab, graf
Article
em En
| LILACS
| ID: lil-410896
Biblioteca responsável:
BR1.1
RESUMO
G protein-coupled receptors (GPCRs) are involved in a large variety of physiological functions. The number of known members that belong to this large family of receptors has been rapidly increasing. Now, with the availability of the human genome sequence databases, further family members are being identified. We describe the identification of a novel GPCR that shows no significant amino acid identity to any one of the known members of the GPCR superfamily. The gene expression pattern of this receptor is restricted in normal tissues it is confined to the nervous system and testis, but we also detected gene expression in several tumor types, most notably prostate cancer, suggesting a potential role for this gene as a marker for this disease.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Neoplasias da Próstata
/
Regulação Neoplásica da Expressão Gênica
/
Receptores Acoplados a Proteínas G
Limite:
Humans
/
Male
Idioma:
En
Revista:
Genet. mol. res. (Online)
Ano de publicação:
2004
Tipo de documento:
Article