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Methylenetetrahydrofolate reductase polymorphisms in myeloid leukemia patients from Northeastern Brazil

Barbosa, Cynara Gomes; Souza, Claudio Lima; Moura Neto, José Pereira de; Arruda, Maria da Glória Bomfim; Barreto, José Henrique; Reis, Mitermayer Galvão; Goncalves, Marilda Souza.
Genet. mol. biol; 31(1): 29-32, 2008. tab
Artigo em Inglês | LILACS | ID: lil-476145
Methylenetetrahydrofolate reductase (MTHFR EC 1.5.1.20) polymorphisms are associated to acute lymphoid leukemia in different populations. We used the polymerase chain reaction and the restriction fragment length polymorphism method (PCR-RFLP) to investigate MTHFR C677T and A1298C polymorphism frequencies in 67 patients with chronic myeloid leukemia (CML), 27 with acute myeloid leukemia FAB subtype M3 (AML-M3) and 100 apparently healthy controls. The MTHFR mutant allele frequencies were as follows CML = 17.2 percent for C677T, 21.6 percent for A1298C; AML-M3 = 22.2 percent for C677T, 24.1 percent for A1298C; and controls = 20.5 percent for C677T, 21 percent for A1298C. Taken together, our results provide evidence that MTHFR polymorphisms have no influence on the development of CML or AML-M3.
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