Morphological and functional characterizations of Schwann cells stimulated with Mycobacterium leprae
Mem. Inst. Oswaldo Cruz
; 103(4): 363-369, June 2008. ilus, graf, tab
Article
em En
| LILACS
| ID: lil-486874
Biblioteca responsável:
BR1.1
ABSTRACT
Nerve damage, a characteristic of leprosy, is the cause of patient deformities and a consequence of Schwann cells (SC) infection by Mycobacterium leprae. Although function/dysfunction of SC in human diseases like leprosy is difficult to study, many in vitro models, including SC lines derived from rat and/or human Schwannomas, have been employed. ST88-14 is one of the cell lineages used by many researchers as a model for M. leprae/SC interaction. However, it is necessary to establish the values and limitations of the generated data on the effects of M. leprae in these SC. After evaluating the cell line phenotype in the present study, it is close to non-myelinating SC, making this lineage an ideal model for M. leprae/SC interaction. It was also observed that both M. leprae and PGL-1, a mycobacterial cell-wall component, induced low levels of apoptosis in ST88-14 by a mechanism independent of Bcl-2 family members.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Contexto em Saúde:
3_ND
Base de dados:
LILACS
Assunto principal:
Células de Schwann
/
Glicolipídeos
/
Apoptose
/
Mycobacterium leprae
/
Antígenos de Bactérias
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2008
Tipo de documento:
Article