Sequential expressions of Notch1, Jagged2 and Math1 in molar tooth germ of mouse
Biocell
; 32(3): 251-258, Dec. 2008. ilus
Article
em En
| LILACS
| ID: lil-541107
Biblioteca responsável:
AR40.1
ABSTRACT
The Notch signaling pathway is an evolutionary conserved mechanism that plays an important role in cell-cell communication and cell fate in a wide range of tissues. The mammalian family of Notch receptors consists of 4 members Notch1/2/3/4. The Notch ligand family consists of 5 members Delta1/3/4 and Jagged1/2. Math1 encodes a murine Basic helix-loop-helix (bHLH) transcription factor that acts as positive regulator of cell differentiation. Recently, links between Notch and Math1 pathways were demonstrated in various tissues. Expression of Notch1, Jagged2 and Math1 were analyzed in the mouse molar tooth germ during embryonic stage (E) 13 and E15 and during postnatal stage (PN) 1, PN3, PN5, PN10 and PN14 by using in situ hybridization. Positive Notch1 expression was found at the tooth bud during embryonic stages, but its expression was absent from the basal cells in contact with the dental mesenchyme. Jagged2 and Math1 were strongly expressed in differentiated ameloblasts and odontoblasts and Math1 strong expression was even maintained until PN14 stage. Math1 showed the strongest expression. Our results suggest that the Notch1 signaling pathway through Jagged2 could be importantly related to Math1, directing the process of odontogenesis toward cell differentiation.
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Germe de Dente
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Transdução de Sinais
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Regulação da Expressão Gênica no Desenvolvimento
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Fatores de Transcrição Hélice-Alça-Hélice Básicos
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Proteínas de Membrana
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Camundongos Endogâmicos BALB C
Limite:
Animals
Idioma:
En
Revista:
Biocell
Ano de publicação:
2008
Tipo de documento:
Article