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Morphological analysis of neonates of rats treated with dexamethasone in the initial phase of pregnancy / Análisis morfológico de neonatos de ratas tratadas con dexametasona en fase inicial de la preñez
Vilaça Júnior, Paulo Estevao Araújo; Teixeira, Alvaro Aguiar Coelho; Wanderley Teixeira, Valéria; Moraes, Eleonora de Figueiredo; Araújo, Ana Claudia Carvalho de; Maia, Carina Scanoni.
Afiliação
  • Vilaça Júnior, Paulo Estevao Araújo; University Federal Rural of Pernambuco. Department of Morphology and Animal Physiology. Recife. BR
  • Teixeira, Alvaro Aguiar Coelho; University Federal Rural of Pernambuco. Department of Morphology and Animal Physiology. Recife. BR
  • Wanderley Teixeira, Valéria; University Federal Rural of Pernambuco. Department of Morphology and Animal Physiology. Recife. BR
  • Moraes, Eleonora de Figueiredo; University Federal Rural of Pernambuco. Department of Morphology and Animal Physiology. Recife. BR
  • Araújo, Ana Claudia Carvalho de; University Federal Rural of Pernambuco. Department of Morphology and Animal Physiology. Recife. BR
  • Maia, Carina Scanoni; University Federal Rural of Pernambuco. Department of Morphology and Animal Physiology. Recife. BR
Int. j. morphol ; 26(3): 523-527, Sept. 2008. ilus, tab
Artigo em Inglês | LILACS | ID: lil-556707
Biblioteca responsável: CL1.1
ABSTRACT
The glucocorticoid dexamethasone has been largely used due to its anti-inflammatory effect. However, several authors report that the excessive exposition to it during pregnancy may cause a retard in the development in several tissues, mainly liver, lungs and kidneys. But, the majority of the works are done with the application of dexamethasone in the late periods of pregnancy. Because of the lack of researches that evaluate the effects in the beginning of gestation, this paper aimed at evaluating the effect of dexamethasone administered in the initial phase of pregnancy, over the morphology of neonates rat. It was used 10 albino rats (Rattus norvegicus albinus) aged 90 days from the lineage Wistar. The female were coupled and divided in two groups Group I - rats not submitted to the dexamethasone application (control); Group II - rats submitted to the dexamethasone application in the first 5 days of pregnancy. The results show that the treatment with dexamethasone in a dosage of 0.8mg/Kg during the 5 first days of pregnancy does not produces a weight and height reduction or malformation in the offspring, it does not cause changes in the development of the liver and kidneys of neonate rats, but it leads to a reduction in the denseness of the interalveolar septa causing a higher distension of the alveoli.
RESUMEN
El glucocorticoide dexametasona ha sido ampliamente utilizado en virtud de su potencial antiinflamatorio. Sin embargo, varios autores relatan que la exposición excesiva a la dexametasona durante la preñez puede causar el retardo del desarrollo de varios tejidos, principalmente hígado, pulmones y riñones. La mayoría de los trabajos son llevados a cabo con la aplicación de dexametasona en los períodos tardíos de la gestación. El objetivo del trabajo fue evaluar el efecto de la dexametasona, sobre la morfología de ratones neonatos, administrada en la fase inicial de la preñez. Fueron utilizadas 10 ratas Wistar albinas (Rattus norvegicus albinus) con 90 días de edad. Las hembras fueron apareadas y divididas en dos grupos Grupo I- ratas no sometidas a la dexametasona (grupo control) y Grupo II - ratas sometidas a la aplicación de dexametasona durante los cinco primeros días de preñez. Los resultados mostraron que el tratamiento con dexametasona en dosis de 0,8mg/Kg, a lo largo de los cinco primeros días de la preñez, no produce reducción de peso, longitud o malformación en la prole, tampoco causa alteraciones en el desarrollo del hígado y riñones en los ratones neonatos, pero sí reduce el grosor de los septos interalveolares, causando de esta manera, mayor distensión de los alvéolos.
Assuntos

Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Alvéolos Pulmonares / Prenhez / Dexametasona Limite: Animais Idioma: Inglês Revista: Int. j. morphol Ano de publicação: 2008 Tipo de documento: Artigo

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Texto completo: Disponível Coleções: Bases de dados internacionais Base de dados: LILACS Assunto principal: Alvéolos Pulmonares / Prenhez / Dexametasona Limite: Animais Idioma: Inglês Revista: Int. j. morphol Ano de publicação: 2008 Tipo de documento: Artigo