Green propolis phenolic compounds act as vaccine adjuvants, improving humoral and cellular responses in mice inoculated with inactivated vaccines
Mem. Inst. Oswaldo Cruz
; 105(7): 908-913, Nov. 2010. ilus, graf
Article
em En
| LILACS
| ID: lil-566182
Biblioteca responsável:
BR1.1
ABSTRACT
Adjuvants play an important role in vaccine formulations by increasing their immunogenicity. In this study, the phenolic compound-rich J fraction (JFR) of a Brazilian green propolis methanolic extract stimulated cellular and humoral immune responses when co-administered with an inactivated vaccine against swine herpesvirus type 1 (SuHV-1). When compared to control vaccines that used aluminium hydroxide as an adjuvant, the use of 10 mg/dose of JFR significantly increased (p < 0.05) neutralizing antibody titres against SuHV-1, as well as the percentage of protected animals following SuHV-1 challenge (p < 0.01). Furthermore, addition of phenolic compounds potentiated the performance of the control vaccine, leading to increased cellular and humoral immune responses and enhanced protection of animals after SuHV-1 challenge (p < 0.05). Prenylated compounds such as Artepillin C that are found in large quantities in JFR are likely to be the substances that are responsible for the adjuvant activity.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Própole
/
Pseudorraiva
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Herpesvirus Suídeo 1
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Vacinas contra Herpesvirus
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Anticorpos Antivirais
Limite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2010
Tipo de documento:
Article