In vitro activity of amphotericin B cochleates against Leishmania chagasi
Mem. Inst. Oswaldo Cruz
; 106(2): 251-253, Mar. 2011. graf, tab
Article
em En
| LILACS
| ID: lil-583954
Biblioteca responsável:
BR1.1
ABSTRACT
Cochleate delivery vehicles are a novel lipid-based system with potential for delivery of amphotericin B (AmB). In this study, the efficacy of cochleates was evaluated by examining the in vitro activity of AmB cochleates (CAMB) against Leishmania chagasi in a macrophage model of infection. We demonstrate that CAMB is nontoxic to macrophages at concentrations as high as 2.5 μg/mL, whereas the conventional formulation, AmB deoxycholate, showed high toxicity at this concentration. The in vitro activity of CAMB against L. chagasi was found to be similar to that of the reference drug AmB deoxycholate, with ED50s of 0.017 μg/mL and 0.021 μg/mL, respectively. Considering that L. chagasi affects organs amenable to cochleate-mediated delivery of AmB, we hypothesize that CAMB will be an effective lipid system for the treatment of visceral leishmaniasis.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Anfotericina B
/
Macrófagos Peritoneais
/
Leishmania infantum
/
Antiprotozoários
Limite:
Animals
Idioma:
En
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2011
Tipo de documento:
Article