Can thymic epithelial cells be infected by human T-lymphotropic virus type 1?
Mem. Inst. Oswaldo Cruz
; 106(6): 759-762, Sept. 2011. ilus
Article
em En
| LILACS
| ID: lil-602062
Biblioteca responsável:
BR1.1
ABSTRACT
The human T-lymphotropic virus type-1 (HTLV-1) is the cause of adult T cell leukaemias/lymphoma. Because thymic epithelial cells (TEC) express recently defined receptors for the virus, it seemed conceivable that these cells might be a target for HTLV-1 infection. We developed an in vitro co-culture system comprising HTLV-1+-infected T cells and human TECs. Infected T cells did adhere to TECs and, after 24 h, the viral proteins gp46 and p19 were observed in TECs. After incubating TECs with culture supernatants from HTLV-1+-infected T cells, we detected gp46 on TEC membranes and the HTLV-1 tax gene integrated in the TEC genome. In conclusion, the human thymic epithelium can be infected in vitro by HTLV-1, not only via cell-cell contact, but also via exposure to virus-containing medium.
Palavras-chave
Texto completo:
1
Coleções:
01-internacional
Base de dados:
LILACS
Assunto principal:
Timo
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Linfócitos T
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Vírus Linfotrópico T Tipo 1 Humano
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Células Epiteliais
Limite:
Humans
Idioma:
En
Revista:
Mem Inst Oswaldo Cruz
/
Mem. Inst. Oswaldo Cruz
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Mem. Inst. Oswaldo Cruz (Online)
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Memórias do Instituto Oswaldo Cruz (Impresso)
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Proceedings of the Instituto Oswaldo Cruz
Ano de publicação:
2011
Tipo de documento:
Article