Declining prevalence of hepatitis A virus antibodies among children from low socioeconomic groups reinforces the need for the implementation of hepatitis A vaccination in Brazil
Mem. Inst. Oswaldo Cruz
; 107(5): 652-658, Aug. 2012. ilus, tab
Artigo
em Inglês
| LILACS
| ID: lil-643751
Biblioteca responsável:
BR1.1
ABSTRACT
Age-related seroprevalence studies that have been conducted in Brazil have indicated a transition from a high to a medium endemicity of hepatitis A virus (HAV) infection in the population. However, most of these studies have focused on urban populations that experience lower incidence rates of HAV infection. In the current study, the prevalence of anti-HAV antibodies was investigated in children with a low socioeconomic status (SES) that live on the periphery of three capital cities in Brazil. A total of 1,162 dried blood spot samples were collected from individuals whose ages ranged from one-18 years and tested for anti-HAV antibodies. A large number of children under five years old (74.1-90%) were identified to be susceptible to HAV infection. The anti-HAV antibody prevalence reached ≥ 50% among those that were 10-14 years of age or older. The anti-HAV prevalence rates observed were characteristics of regions with intermediate level of hepatitis A endemicity. These data indicated that a large proportion of children with a low SES that live at the periphery of urban cities might be at risk of contracting an HAV infection. The hepatitis A vaccine that is currently offered in Brazil is only available for high-risk groups or at private clinics and is unaffordable for individuals with a lower SES. The results from this study suggest that the hepatitis A vaccine should be included in the Brazilian National Program for Immunisation.
Texto completo:
Disponível
Coleções:
Bases de dados internacionais
Temas:
Aperfeiçoar a gestão do SUS
Contexto em Saúde:
Agenda de Saúde Sustentável para as Américas 2030 - ASSA2030
/
ODS3 - Saúde e Bem-Estar
Base de dados:
LILACS
Assunto principal:
Vírus da Hepatite A Humana
/
Vacinas contra Hepatite A
/
Anticorpos Anti-Hepatite A
/
Hepatite A
Tipo de estudo:
Estudo observacional
/
Estudo de prevalência
/
Estudo prognóstico
/
Fatores de risco
Aspecto:
Determinantes_sociais_saude
Limite:
Adolescente
/
Criança
/
Criança, pré-escolar
/
Feminino
/
Humanos
/
Lactente
/
Masculino
País/Região como assunto:
América do Sul
/
Brasil
Idioma:
Inglês
Revista:
Mem. Inst. Oswaldo Cruz
Ano de publicação:
2012
Tipo de documento:
Artigo
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